As a college pastor, there are a few very common conversations I have always had with several students like it was the first time. One of those conversations walks students through following God's intent for their lives to the chagrin and often in the face of their parents' intent for them.
Acts 21:10-14 shows Paul being clear of God's intent for his life in the face of people who love him. They are people who deeply care for Paul, and he knows that is the reason it breaks his heart so much when he sees their advice and strong intent going against what he KNOWS God has told him to do.
This stress of the tension between disappointing those who care for you in order to follow God's intent for you is one I hear all the time.
There has to be a challenge here for all of us to answer God's call while realizing it is not what our loved ones will aways want for us.